Screening, Optimization of Medium and Solid State Fermentation for L-asparaginase Production
نویسندگان
چکیده
The enzyme L-asparaginase has been proved to be efficient in treatment of Acute Lymphoblastic Leukemia [ALL] and Lymphosarcomas. The present paper discusses the studies carried out for the production of this enzyme from bacillus species. By study obtained optimization of medium, solid state fermentation by using cotton cake and wheat bran and submerged fermentation using distillery waste. a M2 modified medium has optimal L-asparaginase production. The enzyme activity (4.58EU/mL) markedly increases in M2 modified medium (62.33EU/mL), solid state fermentation has shows desired enzyme production in cotton cake (68.00EU/mL), and wheat bran(22.91EU/mL).in distillery waste carried submerged fermentation for L-asparaginase production.
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